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KMID : 0978920030040040039
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Korean Journal of Clinical Geriatrics
2003 Volume.4 No. 4 p.39 ~ p.46
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Change of Bone Mass Density as Iniection of Calcitonin-microsphere in Osteoporosis-Induced Rats
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Choi Jeong-Won
Chung Jae-Soon
Lee Sang-Gun
Paik Doo-Jin
Park Ile-Kyu
Park Yong-Koo
Kim Mi-Jung
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Abstract
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Objective: To evaluate bone protective effects of salmon C떠citonin microspheres aganist cancellous bone loss in ovariectomized rats.
Method: Thirty five osteoporosis-induced Sprague-Dawley rats were randomly divided into five groups (high
dose calcitonin group (112 U/kg), low dose calcitonin group (56 U/kg), free calcitonin group, only ovariectomy group, control group). Ovariectomized rats were i띠 ected s.c. with salmon calcitonin microspheres(l 12 U/kg or 56 U/kg) weekly, and free salmon calcitonin on alternate days. control rats and the remaining ovariectomized rats were i매ected s.c. on alternate days with saline vehicle. The effects and side effects in each group were assessed by the bone mineral density and bone histomorphomeσy.
Results: 1. At four months after the ovariectomy, the bone mineral densities in high dose calcitonin group were
0.1640±0.0156 grn/cm2, the bone miner떠 densities in low dose cakitonin group were 0.16α}±0.0114 grn/cm2, the bone mineral densities in calcitonin group were 0.1531 土0.0168 grn/cm2, the bone mineral densities in ovariectomy group were 0.1404土0 . 0070 gm/cm2, the bone mineral densities in control group were 0.1896土0.0163 gm/cm2. The bone mineral densities of the femur in ovrariectomy groups compared with control group were decreased with time. π1e difference of the bone mineral densities between hig뇨-and low dose calcitonin group and ovariectomy groups was significant (p<0.05).
2. We found that the bone trabeculi in bone histomophometry were more maintained in high dose calcitonin group compared with ovariectomy group.
Conclusion: I. Bone mineral densities of salmon calcitonin rnicrosphere injected rats was higher than only ovariectomized rats in femur. 2. Bone mineral densities of s떠mon calcitonin microsphere injected rats had no significant differences than only ovariectomized rats in LS vertebra. 3. ln 비stologic examination, salmon calcitonin microsphere and free salmon calcitonin injected rats showed more prominent bony σabec비ae than ovariectomized rats.
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KEYWORD
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Osteoporosis, Ca!citonin-microsphere, Bone mineral density, Bone histomorphometry
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